Bempedoic acid and its fixed combination drug product with ezetimibe were approved in the European Union and the United States earlier this year with different labels … Professional resources. What is bempedoic acid? Bempedoic acid is also used to lower LDL cholesterol in adults with coronary artery disease (clogged arteries). Bempedoic acid was not teratogenic in rats and rabbits when administered at doses resulting in exposures up to 11 and 12 times, respectively, the human exposures at the maximum clinical dose, based on AUC; Lactation. Oral: May be administered without regard to food. Consider therapy modification, Voxilaprevir: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Voxilaprevir. Follow all directions on your medicine label and package. 6, 7 It was developed by … Bempedoic acid is a first-in-class oral adenosine triphosphate (ATP) citrate lyase inhibitor being evaluated as an additional treatment option for high-risk patients requiring further reduction in LDL-C. Bempedoic acid … Hepatic; primarily through metabolism of the acyl glucuronide; reversibly converted by aldo-keto reductase enzyme to an active metabolite (ESP15228), which is also converted to a glucuronide conjugate. Tendon problems may be more likely in certain people (older adults, people with kidney disease, or people who take steroid medicine or certain antibiotics. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Copyright 1996-2021 Cerner Multum, Inc. The evaluation of ICER will be ongoing over the next … Drug Class1,2,3,4,5: adenosine triphosphate-citrate lyase (ACL) inhibitor, antilipemic agent . Generic Name: bempedoic acid (BEM pe DOE ik AS id)Brand Name: NexletolDosage Forms: oral tablet (180 mg). ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. Specifically, concentrations of elagolix may be increased. ... On Feb. 21, 2020, the Food and Drug Administration (FDA) provided approval for the use of bempedoic acid… However, many people have no side effects or only have minor side effects. low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet. Do not take two doses at one time. Bempedoic acid belongs to a group of drugs called adenosine triphosphate-citrate lyase inhibitors. Atherosclerotic cardiovascular disease, established: Oral: 180 mg once daily. Bempedoic acid is a non-statin, targeted therapy designed to primarily work in the liver to inhibit cholesterol biosynthesis. Other drugs may affect bempedoic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Written by Cerner Multum. Note: This is not a comprehensive list of all side effects. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibiting cholesterol synthesis in the liver. Consider therapy modification, Grazoprevir: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Grazoprevir. We comply with the HONcode standard for trustworthy health information -, heterozygous familial hypercholesterolemia, Drug class: miscellaneous antihyperlipidemic agents. Management: Decrease the eluxadoline dose to 75 mg twice daily if combined with OATP1B1/1B3 inhibitors and monitor patients for increased eluxadoline effects/toxicities. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Store in original package (with desiccant) at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Bempedoic acid may cause swelling or tearing of a tendon (the fiber that connects bones to muscles in the body), especially in the arm, shoulder, or Achilles' tendon of the heel. This can happen within days or months after you start taking bempedoic acid. Inhibition of ACL by ETC-1002-CoA results in decreased cholesterol synthesis in the liver and lowers LDL-C in blood via upregulation of LDL receptors. Bempedoic acid is first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor used once a day for reducing LDL cholesterol levels in statin-refractory patients. >10%: Endocrine & metabolic: Gout (2% [placebo: 0.4%]; with prior gout history: 11% [placebo: 2%]), hyperuricemia (4% to 26% [placebo: 1% to 10%]), Cardiovascular: Atrial fibrillation (2%), increased serum creatine kinase (1%), Gastrointestinal: Abdominal distress (≤3%), abdominal pain (≤3%), Genitourinary: Benign prostatic hyperplasia (1%), Hematologic & oncologic: Anemia (3%), leukopenia (9%), thrombocythemia (10%), Hepatic: Increased liver enzymes (2%), increased serum aspartate aminotransferase (1%), Neuromuscular & skeletal: Back pain (3%), limb pain (3%), muscle spasm (4%), Renal: Increased blood urea nitrogen (4%), increased serum creatinine (2%), Respiratory: Upper respiratory tract infection (5%), <1%: Neuromuscular & skeletal: Rupture of tendon (placebo: 0%). -Lipid levels should be checked within 8 to 12 weeks of treatment initiation. Nexletol (bempedoic acid) is a first-in-class, adenosine triphosphate-citrate lyase (ACL) inhibitor for the treatment of adults with heterozygous familial hypercholesterolemia or established … Bempedoic acid, sold under the brand name Nexletol among others, is a medication for the treatment of hypercholesterolemia (high blood cholesterol levels). Use the medicine exactly as directed. Talk to your doctor if you have questions. Consider alternative therapy in patients with a history of tendon disorders or tendon rupture. Uses: As an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in those requiring additional LDL-C lowering. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. Pharmacokinetics were not affected by weight. Call your doctor for medical advice about side effects. Monitor lipid levels within 8 to 12 weeks of therapy initiation; signs/symptoms of hyperuricemia, assess uric acid levels as clinically indicated; signs/symptoms of tendon rupture (eg, joint pain, swelling, inflammation). Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Bempedoic acid is for use in adults with an inherited form of high cholesterol. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers low-density lipoprotein cholesterol (LDL-C) by inhibiting cholesterol synthesis in the liver. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. Avoid combination, Elagolix, Estradiol, and Norethindrone: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Elagolix, Estradiol, and Norethindrone. Side Effects; During Pregnancy; Drug Interactions; En Español; Drug class: miscellaneous antihyperlipidemic agents; Consumer resources. Avoid combination, Pravastatin: Bempedoic Acid may increase the serum concentration of Pravastatin. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Avoid combination, Simvastatin: Bempedoic Acid may increase the serum concentration of Simvastatin. Learn about bempedoic acid and the CLEAR program. • Hyperuricemia: Increases in serum uric acid have occurred, usually within the first 4 weeks of treatment initiation, and persisted throughout treatment. Nexletol (bempedoic acid) is a member of the miscellaneous antihyperlipidemic agents drug class and is commonly used for High Cholesterol - Familial Heterozygous. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. What is bempedoic acid and ezetimibe? Follow all directions on your prescription label and read all medication guides or instruction sheets. Available for Android and iOS devices. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Bempedoic acid; Other brands: Nexletol. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Refer to adult dosing. Bempedoic acid is used together with diet and other medicines to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL). ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol bi… This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Medically reviewed by Drugs.com. Consider discontinuing therapy if joint pain, swelling, or inflammation occurs; discontinue immediately if tendon rupture occurs. All drugs may cause side effects. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet. Nexlizet contains two medicines … Feces (30%; <5% as unchanged drug); urine (<5% as unchanged drug; ~70% of total dose as bempedoic acid and metabolites). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Bempedoic acid is used together with diet and other medicines to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL). Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. ACL is an enzyme upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. bempedoic acid is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. The findings come from the largest study to date to test the effectiveness and safety of bempedoic acid… The drug, bempedoic acid, is the first in a new class of drugs to treat low-density-lipoprotein cholesterol, also called “bad” cholesterol, which causes the buildup of fatty deposits … Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs … Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Bempedoic acid and its active metabolite, ESP15228, require coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1) to ETC-1002-CoA and ESP15228-CoA, respectively. Avoid combination, Eluxadoline: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase the serum concentration of Eluxadoline. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A new class of oral cholesterol-lowering drug could help patients unable to take statins due to side effects. Heterozygous familial hypercholesterolemia: Oral: 180 mg once daily. How … Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. … Bempedoic acid may also be used for purposes not listed in this medication guide. Consider therapy modification, Revefenacin: OATP1B1/1B3 (SLCO1B1/1B3) Inhibitors may increase serum concentrations of the active metabolite(s) of Revefenacin. But statins are also thought to affect cholesterol … Note: Use is recommended in combination with maximally tolerated statin therapy. In general, bempedoic acid should be discontinued if pregnancy occurs. Bempedoic acid and ezetimibe is a combination medicine that is used to lower blood levels of "bad" cholesterol (low-density … “Bempedoic acid (Esperion Therapeutics) is a first-in-class small molecule inhibitor of ATP citrate lyase, an enzyme upstream of HMG-CoA reductase in cholesterol … The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. This is not a complete list of side effects and others may occur. ... "What we have is a new class of drug that could be given to … Avoid combination. Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: • Unable to move or put weight on a joint, • Hear or feel a snap or pop in a joint, • Tendon inflammation or rupture like pain, bruising, or swelling in the back of the ankle, shoulder, hand, or other joints.